IRB Faculty
The Medical &
Scientific Research Directorate
Prof. Kwasi A. Bugyei
D.V.M, B.VSc, MSc, PhD.
Associate Professor/Pharmacology and Toxicology
kabugyei@ug.edu.gh | +233-242- 545979 |
Education
- D.V.M. (Veterinary Medicine), University of Ljubljana, Slovenia, 1983.
- BVSc. (Public Health and Food Inspection), University of Ljubljana, Slovenia, 1984.
- M.Sc, Toxicology: University of Guelph, ON, Canada (1992)
- Ph.D, Pharmacology: University of Guelph, ON, Canada (1995)
Board Certifications
Certified, Ghana Veterinary Council
Research Interest
My research interests focus on the following areas:
1. Pharmacological and toxicological effects of plant medicines. To this effect, medicinal plants and nutraceuticals are studied using both in vitro and in vivo models to elucidate efficacy, possible mechanisms of action and toxicity of plan medicines and food supplements.
2. Pharmacokinetics of medicines. The focus here is on pharmacokinetic profile of drugs given concomitantly to target species. Results from such drug-drug interaction studies give us the opportunity to work out new dosage regime suitable for the judicious use of drugs.
3. Microbial resistance to antimicrobial agents. This involves the studies of microbial resistance to antibiotics and antihelminthics using DNA extraction, Polymerase Chain Reaction and Genotyping to identify and elucidate possible mechanisms of microbial resistance to commonly used anti-infectives.
1. Pharmacological and toxicological effects of plant medicines. To this effect, medicinal plants and nutraceuticals are studied using both in vitro and in vivo models to elucidate efficacy, possible mechanisms of action and toxicity of plan medicines and food supplements.
2. Pharmacokinetics of medicines. The focus here is on pharmacokinetic profile of drugs given concomitantly to target species. Results from such drug-drug interaction studies give us the opportunity to work out new dosage regime suitable for the judicious use of drugs.
3. Microbial resistance to antimicrobial agents. This involves the studies of microbial resistance to antibiotics and antihelminthics using DNA extraction, Polymerase Chain Reaction and Genotyping to identify and elucidate possible mechanisms of microbial resistance to commonly used anti-infectives.
Selected Publications
1. G. A. Asare, K. Bugyei, A. Sittie, E. S. Yahaya, B. Gyan, S. Adjei, P. Addo, E. K. Wiredu, D. N. Adjei and A.K. Nyarko. Genotoxicity, cytotoxicity and toxicological evaluations of whole plant extracts of the medicinal plant Phyllanthus niruri (Phyllanthaceae). Genetic and Molecular Research 2012. 11(1): 100-111)
2. George A. Asare, Ben A. Gyan, Kwasi Bugyei, Samuel Adjei, Razak Mahama, Phillis Addo, Edwin K. Wiredu, Alex K. Nyarko. Toxicity potentials of the nutraceutical Moringa oleifera at supra-supplementation levels. J. Ethnopharmacology. 2012. 139 (1): 265-272
3. Seth K. Amponsah, Kwasi A. Bugyei, Dorcas. Osei-Sarfo, F. Kwaku Addai, George Asare, Emmanuel A. Tsegah, Joseph Baah, Michael Ofori and Ben Gyan. In vitro activity and fractions of natural cocoa powder on Plasmodium falciparum and inflammatory response mechanisms in malaria. J. Medicinal Foods. 2012. 15 (0): 1-7
4. Isaac Julius Asiedu-Gyekye, Daniel Ansong Antwi, Kwasi Agyei Bugyei and Charles Awortwe. Comparative study of two Kalanchoe species: total flavonoid, phenolic contents and antioxidant properties. African J. Pure and Applied Chemistry. 2012. Vol 6 (5): 65-73
5. Godwin Sokpor, Frederick Kwaku Addai, Richard Kwasi Gyasi, Kwasi A. Bugyei, John Ahenkorah and Bismarck Hotor.Voluntary Ingestion of Natural Cocoa Extenuated Hepatic Damage in Rats with Experimentally Induced Chronic Alcoholic Toxicity. Functional Foods in Health and Disease. 2012. 2 (5): 166-187
6. Eric Aidoo, Frederick K. Addai, John Ahenkorah, Bismarck Hottor, Kwasi A. Bugyei. Ben A. Gyan. Natural cocoa ingestion reduced liver damage in mice infected with Plasmodium berghei (NK65). Research and Reports in Tropical Medicine. 2012. 3: 107 - 116
7. Dan K. Afriyie, George A. Asare, Kwasi Bugyei, Isaac Asiedu-Gyekye, Ben A. Gyan, Samuel Adjei, Phillis Addo, Archibald Sittie, and Alexander K. Nyarko. Anti-atherogenic and anti-ischemic potentials of Croton membranaceus observed during sub-chronic toxicity studies. Pharmacognosy Research. 2013. 5: 10-16
8. Asare George, Bugyei Kwasi, Fiawoyi Irene, Gyan Ben, Adjei Samuel, Addo Phyllis, Otu-Nyarko Lydia and Nyarko Alexander. Male rat hormone imbalance, testicular changes and toxicity associated with aqueous leaf extract of an antimalarial plant: Phyllanthus niruri. Pharmaceutical Biology. 2013. 51 (6): 691-699
9. Asiedu-Gyekye IJ, Antwi DA, Bugyei KA, Awortwe C, and N’guessan BB. Vascular effect of an aqueous extract of Kalanchoe integra var. crenata (Andr.) Cuf leaves: Reversal of postischaemic dysautoregulation in a rat model of cerebral ischaemia. Journal of Physiology and Pharmacology Advances. 2013. 3(4): 103-109
10. Dan K. Afriyie, George Awuku Asare, Kwasi Bugyei, Isaac Julius Asiedu-Gyekye, Richmond Tackie, Samuel Adjei. Prostate specific targeting of the aqueous root extract of Croton membranaceus in experimental animals. Andrologia. 2013. (accepted for publication, May 29, 2013)
11. Daniel K. Afriyie, George A. Asare, K. Bugyei, Samuel Adjei, Jiu-mao Lin, Jun Peng, Zhen-feng Hong. Treatment of benign prostatic hyperplasia with Croton membranaceus in an experimental animal model. Journal of Ethnopharmacology. 2014. 157: 90-98
12. D.K. Afriyie, G.A. Asare, K. Bugyei, J. Lin, J. Peng and Z. Hong. Mitochondria-dependent apoptogenic activity of the aqueous root extract of Croton membranaceus against human BPH-cells. Genetic and Molecular Research. 2015. 14: 149-162
13. Titus Beyuo, Samuel Amenyi Obed, Kenneth Kweku Adjepong-Yamoah, Kwasi Agyei Bugyei, Samuel Antwi Oppong, Kissinger Marfoh. Metformin versus Insulin in the Management of Pre-Gestational Diabetes Mellitus at the Korle-Bu Teaching Hospital: A Randomized Clinical Trial. PLOS ONE | DOI: 10. 1371/journal.pone.0125712. May 6, 2015
14. Seth K. Amponsah, George O. Adjei, Christabel Enweronu-Laryea, Kwasi A. Bugyei, Kosta Hadji-Popovski, Jorgen A.L. Kurtzals, Kim Kristensen. Population Pharmacokinetics Characteristics of Amikacin in Suspected Cases of Neonatal Sepsis in a Low-Resource African Setting: A Prospective Nonrandomized Single-Site Study. Current Therapeutic Research. 2017
15. Sherry Johnson, Kwasi Bugyei, Priscillia Nortey and William Tasiame. Antimicrobial drug usage in poultry production in Dormaa municipality, Brong Ahafo region of Ghana. Animal Production Science. 2017. DOI:10.1071/AN16832.
2. George A. Asare, Ben A. Gyan, Kwasi Bugyei, Samuel Adjei, Razak Mahama, Phillis Addo, Edwin K. Wiredu, Alex K. Nyarko. Toxicity potentials of the nutraceutical Moringa oleifera at supra-supplementation levels. J. Ethnopharmacology. 2012. 139 (1): 265-272
3. Seth K. Amponsah, Kwasi A. Bugyei, Dorcas. Osei-Sarfo, F. Kwaku Addai, George Asare, Emmanuel A. Tsegah, Joseph Baah, Michael Ofori and Ben Gyan. In vitro activity and fractions of natural cocoa powder on Plasmodium falciparum and inflammatory response mechanisms in malaria. J. Medicinal Foods. 2012. 15 (0): 1-7
4. Isaac Julius Asiedu-Gyekye, Daniel Ansong Antwi, Kwasi Agyei Bugyei and Charles Awortwe. Comparative study of two Kalanchoe species: total flavonoid, phenolic contents and antioxidant properties. African J. Pure and Applied Chemistry. 2012. Vol 6 (5): 65-73
5. Godwin Sokpor, Frederick Kwaku Addai, Richard Kwasi Gyasi, Kwasi A. Bugyei, John Ahenkorah and Bismarck Hotor.Voluntary Ingestion of Natural Cocoa Extenuated Hepatic Damage in Rats with Experimentally Induced Chronic Alcoholic Toxicity. Functional Foods in Health and Disease. 2012. 2 (5): 166-187
6. Eric Aidoo, Frederick K. Addai, John Ahenkorah, Bismarck Hottor, Kwasi A. Bugyei. Ben A. Gyan. Natural cocoa ingestion reduced liver damage in mice infected with Plasmodium berghei (NK65). Research and Reports in Tropical Medicine. 2012. 3: 107 - 116
7. Dan K. Afriyie, George A. Asare, Kwasi Bugyei, Isaac Asiedu-Gyekye, Ben A. Gyan, Samuel Adjei, Phillis Addo, Archibald Sittie, and Alexander K. Nyarko. Anti-atherogenic and anti-ischemic potentials of Croton membranaceus observed during sub-chronic toxicity studies. Pharmacognosy Research. 2013. 5: 10-16
8. Asare George, Bugyei Kwasi, Fiawoyi Irene, Gyan Ben, Adjei Samuel, Addo Phyllis, Otu-Nyarko Lydia and Nyarko Alexander. Male rat hormone imbalance, testicular changes and toxicity associated with aqueous leaf extract of an antimalarial plant: Phyllanthus niruri. Pharmaceutical Biology. 2013. 51 (6): 691-699
9. Asiedu-Gyekye IJ, Antwi DA, Bugyei KA, Awortwe C, and N’guessan BB. Vascular effect of an aqueous extract of Kalanchoe integra var. crenata (Andr.) Cuf leaves: Reversal of postischaemic dysautoregulation in a rat model of cerebral ischaemia. Journal of Physiology and Pharmacology Advances. 2013. 3(4): 103-109
10. Dan K. Afriyie, George Awuku Asare, Kwasi Bugyei, Isaac Julius Asiedu-Gyekye, Richmond Tackie, Samuel Adjei. Prostate specific targeting of the aqueous root extract of Croton membranaceus in experimental animals. Andrologia. 2013. (accepted for publication, May 29, 2013)
11. Daniel K. Afriyie, George A. Asare, K. Bugyei, Samuel Adjei, Jiu-mao Lin, Jun Peng, Zhen-feng Hong. Treatment of benign prostatic hyperplasia with Croton membranaceus in an experimental animal model. Journal of Ethnopharmacology. 2014. 157: 90-98
12. D.K. Afriyie, G.A. Asare, K. Bugyei, J. Lin, J. Peng and Z. Hong. Mitochondria-dependent apoptogenic activity of the aqueous root extract of Croton membranaceus against human BPH-cells. Genetic and Molecular Research. 2015. 14: 149-162
13. Titus Beyuo, Samuel Amenyi Obed, Kenneth Kweku Adjepong-Yamoah, Kwasi Agyei Bugyei, Samuel Antwi Oppong, Kissinger Marfoh. Metformin versus Insulin in the Management of Pre-Gestational Diabetes Mellitus at the Korle-Bu Teaching Hospital: A Randomized Clinical Trial. PLOS ONE | DOI: 10. 1371/journal.pone.0125712. May 6, 2015
14. Seth K. Amponsah, George O. Adjei, Christabel Enweronu-Laryea, Kwasi A. Bugyei, Kosta Hadji-Popovski, Jorgen A.L. Kurtzals, Kim Kristensen. Population Pharmacokinetics Characteristics of Amikacin in Suspected Cases of Neonatal Sepsis in a Low-Resource African Setting: A Prospective Nonrandomized Single-Site Study. Current Therapeutic Research. 2017
15. Sherry Johnson, Kwasi Bugyei, Priscillia Nortey and William Tasiame. Antimicrobial drug usage in poultry production in Dormaa municipality, Brong Ahafo region of Ghana. Animal Production Science. 2017. DOI:10.1071/AN16832.