IRB Faculty
The Medical &
Scientific Research Directorate
Dr. Kwame B. N. Banga
BSc., MPhil., PhD.
Senior Lecturer-Department of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences-UG
bbnguessan@ug.edu.gh | +233-544-779408 |
Education
- BSc Biochemistry, Felix Houphouet-Boigny University, Cote d’Ivoire (1995)
- MPhil, Pharmacology (1998) and PhD Pharmacology (2003), University of Strasbourg, France
- Research Fellowship, Institute of Molecular and Cellular Biology: University of Strasbourg, France (2005)
- Research Fellowship, Department of Therapeutic Innovation, Faculty of Pharmacy, University of Strasbourg, France (2008) · Research Fellowship, Institute of Traditional Chinese Medicine, Tianjin, China (2019)
Board Certifications
- Certified, Traditional Medicine Practice Council, Ghana
Research Interest
My research interests focus on ethnopharmacology-oriented drug discovery in oxidative stress-induced non-communicable diseases with emphasis on cancer, diabetes and asthma
Current projects
1. Chemoprotective activity of D-Ribose-L-Cysteine (Riboceine) against the cytotoxic effects of methotrexate and docetaxel on normal and cancer cell lines
2. Effect of cellgevity®, a glutathione-enhancer dietary supplement, on streptozotocin-induced type-2 diabetes and nephrotoxicity in rat
3. Effect of Metaswitch® supplement on anthropometric parameters, serum lipids, glucose levels and oxidative stress in a high fat diet-induced overweight rat model.
4. Investigating the drug interaction potential of Cellgevity® on selected CYP 450 enzymes in Sprague-Dawley rats.
Current projects
1. Chemoprotective activity of D-Ribose-L-Cysteine (Riboceine) against the cytotoxic effects of methotrexate and docetaxel on normal and cancer cell lines
2. Effect of cellgevity®, a glutathione-enhancer dietary supplement, on streptozotocin-induced type-2 diabetes and nephrotoxicity in rat
3. Effect of Metaswitch® supplement on anthropometric parameters, serum lipids, glucose levels and oxidative stress in a high fat diet-induced overweight rat model.
4. Investigating the drug interaction potential of Cellgevity® on selected CYP 450 enzymes in Sprague-Dawley rats.
Selected Publications
1. Seth K. Amponsah, Benoit B. N’guessan*, Martin Akandawen, Abigail Aning, Sedem Y. Agboli, Eunice A. Danso, Kwabena FM. Opuni, Isaac J. Asiedu-Gyekye, and Regina Appiah-Opong. Effect of Cellgevity® Supplement on Selected Rat Liver Cytochrome P450 Enzyme Activity and Pharmacokinetic Parameters of Carbamazepine. Evidence-Based Complementary and Alternative Medicine, volume 2020, Article ID 7956493, 8 pages, https://doi.org/10.1155/2020/7956493. *Co-first and corresponding author
2. Kukuia KKE, Mensah JA, Amoateng P, Amponsah SK, N'Guessan BB, Asiedu-Gyekye IJ: Antidepressant Potentials of Components from Trichilia monadelpha (Thonn.) J.J. de Wilde in Murine Models. Evidence-Based Complementary & Alternative Medicine 2018, 2018:6863973.
3. Kennedy K.E. Kukuia, Jeffrey A. Mensah, Patrick Amoateng, Seth K. Amponsah, Benoit B. N’Guessan, and Isaac Julius Asiedu-Gyekye. Antidepressant Potentials of Components from Trichilia monadelpha (Thonn.) J.J. de Wilde in Murine Models, 2018 Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2018/6863973
4. Benoit B. N’guessan, Seth K. Amponsah, George J. Dugbartey, Kwabena D. Awuah, Eunice Dotse, Abigail Aning, Kennedy K.E. Kukuia, Isaac J. Asiedu-Gyekye, Regina Appiah-Oppong. In Vitro Antioxidant Potential and Effect of a Glutathione-Enhancer Dietary Supplement on Selected Cytochrome P450 Enzyme Activity 2018. Evidence-Based and Complementary Medicine 2018(3):1-8
5. Amoateng P, Adjei S, Osei-Safo D, Kukuia KKE, Kretchy IA, Sarkodie JA, N'Guessan BB. "Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in rats". BMC Res Notes. 2017 Jun 26;10(1):226. doi: 10.1186/s13104-017-2551-7.
6. Nettey, Henry, Grace Lovia Allotey-Babington, Isaac Somuah, N’guessan Benoit Banga, Barima Afrane, Seth Kwabena Amponsah, Henrietta Annor et al. "Assessment of Formulated Amodiaquine Microparticles in Leishmania Donovani infected Rats". J Microencapsul. 2017 Feb;34(1):21-28. doi: 10.1080/02652048.2017.1280094.
7. Asiedu-Gyekye, Isaac Julius, Mahmood Abdulai Seidu, Banga Benoit N’guessan, Samuel Frimpong–Manso, Joseph Edusei Sarkodie, Samuel Adjei, Schevadnazy Kutu, Joseph Osei-Little, Alexander Kwadwo Nyarko, and Philip Debrah. "A dietary strategy for the management of artemether-lumefantrine-induced cardiovascular and renal toxicity." BMC Complementary and Alternative Medicine 16, no. 1 (2016): 348.
8. Asiedu-Gyekye, Isaac Julius, Samuel Frimpong-Manso, Benoit Banga N’guessan, Mahmood Abdulai Seidu, Paul Osei-Prempeh, and Daniel Kwaku Boamah. "Macro-and Microelemental Composition and Toxicity of Unsweetened Natural Cocoa Powder in Sprague-Dawley Rats." Journal of Toxicology 2016 (2016).
9. Asiedu-Gyekye, Isaac Julius, Kennedy Kwami Edem Kukuia, Abdulai Mahmood Seidu, Charles Antwi-Boasiako, Benoit Banga N’guessan, Samuel Frimpong-Manso, Samuel Adjei, Jonathan Zobi, Abraham Terkpertey Tettey, and Alexander Kwadwo Nyarko. "Unsweetened Natural Cocoa Powder Has the Potential to Attenuate High Dose Artemether-Lumefantrine-Induced Hepatotoxicity in Non-Malarious Guinea Pigs." Evidence-Based Complementary and Alternative Medicine 2016 (2016).
10. Amoateng, Patrick, Samuel Adjei, Dorcas Osei-Safo, Believe Ahedor, Seidu A. Mahmood, Benoit B. N’guessan, Isaac J. Asiedu-Gyekye, and Alexander K. Nyarko. "Long-term continuous administration of a hydro-ethanolic extract of Synedrella nodiflora (L) Gaertn in male Sprague-Dawley rats: biochemical, haematological and histopathological changes." Ghana Medical Journal 50, no. 3 (2016): 163-171.
11. Benoit Banga Nguessan*, Kassim Dosso, Boua Narcisse Gnangoran, Patrick Amoateng, Isaac Julius Asiedu-Gyekye, Angoue Paul Yapo: Antibacterial and antispasmodic activities of a dichloromethane fraction of an ethanol extract of stem bark of Piliostigma reticulatum. Journal of Pharmacy & Bioallied Sciences (2015), 7(2) :128-135. *Corresponding author
12. Patrick Amoateng, Samuel Adjei, Dorcas Osei-Safo, Elvis Ofori Ameyaw, Believe Ahedor, Benoit Banga N’guessan, Alexander Kwadwo Nyarko: A hydro-ethanolic extract of Synedrella nodiflora (L.) Gaertn ameliorates hyperalgesia and allodynia in vincristine-induced neuropathic pain in rats. Journal of Basic and Clinical Physiology and Pharmacology (2015), DOI:10.1515/jbcpp-2014-0084.
13. Benoit N’guessan*, Boua Gnangoran, Joseph Sarkodie, Kassim Dosso, Irene Kretchy, Patrick Amoateng, Isaac Asiedu-Gyekye, David Owusu, Alexander Nyarko, Angoue Yapo: Alternative to Conventional Diabetic Management: The Antihyperglycaemic potential of an Ethyl Acetate Fraction Extract of Holarrhena floribunda. European journal of Medicinal plants (2015), 8(4) :175-189. DOI :10.9734/EJMP/2015/17748. *Corresponding author
14. Benoit N’guessan*, Hervé Sanchez, Joffrey Zoll, Florence Ribera, Stéphane Dufour, Eliane Lampert, Michel Kindo, Bernard Geny, Renée Ventura-Clapier, Bertrand Mettauer. Oxidative capacities of cardiac and skeletal muscles of heart transplant recipients: mitochondrial effects of cyclosporin-A and its vehicle Cremophor-EL. Fundam Clin Pharmacol. (2014), Apr; 28(2):151-60. *Corresponding author.
15. K. Dosso, B.B. N’guessan*, A.P. Bidie, B.N. Gnangoran, S. Méité, D. N’guessan, A.P. Yapo, E.E. Ehilé. Antidiarrhoeal activity of an ethanol extract of the stem bark of Piliostigma reticulatum (Caesapiniaceae) in rats. Afr J Tradit Complement Altern Med. (2012), 9(2): 242-249. Corresponding author.
2. Kukuia KKE, Mensah JA, Amoateng P, Amponsah SK, N'Guessan BB, Asiedu-Gyekye IJ: Antidepressant Potentials of Components from Trichilia monadelpha (Thonn.) J.J. de Wilde in Murine Models. Evidence-Based Complementary & Alternative Medicine 2018, 2018:6863973.
3. Kennedy K.E. Kukuia, Jeffrey A. Mensah, Patrick Amoateng, Seth K. Amponsah, Benoit B. N’Guessan, and Isaac Julius Asiedu-Gyekye. Antidepressant Potentials of Components from Trichilia monadelpha (Thonn.) J.J. de Wilde in Murine Models, 2018 Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2018/6863973
4. Benoit B. N’guessan, Seth K. Amponsah, George J. Dugbartey, Kwabena D. Awuah, Eunice Dotse, Abigail Aning, Kennedy K.E. Kukuia, Isaac J. Asiedu-Gyekye, Regina Appiah-Oppong. In Vitro Antioxidant Potential and Effect of a Glutathione-Enhancer Dietary Supplement on Selected Cytochrome P450 Enzyme Activity 2018. Evidence-Based and Complementary Medicine 2018(3):1-8
5. Amoateng P, Adjei S, Osei-Safo D, Kukuia KKE, Kretchy IA, Sarkodie JA, N'Guessan BB. "Analgesic effects of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L.) Gaertn in paclitaxel-induced neuropathic pain in rats". BMC Res Notes. 2017 Jun 26;10(1):226. doi: 10.1186/s13104-017-2551-7.
6. Nettey, Henry, Grace Lovia Allotey-Babington, Isaac Somuah, N’guessan Benoit Banga, Barima Afrane, Seth Kwabena Amponsah, Henrietta Annor et al. "Assessment of Formulated Amodiaquine Microparticles in Leishmania Donovani infected Rats". J Microencapsul. 2017 Feb;34(1):21-28. doi: 10.1080/02652048.2017.1280094.
7. Asiedu-Gyekye, Isaac Julius, Mahmood Abdulai Seidu, Banga Benoit N’guessan, Samuel Frimpong–Manso, Joseph Edusei Sarkodie, Samuel Adjei, Schevadnazy Kutu, Joseph Osei-Little, Alexander Kwadwo Nyarko, and Philip Debrah. "A dietary strategy for the management of artemether-lumefantrine-induced cardiovascular and renal toxicity." BMC Complementary and Alternative Medicine 16, no. 1 (2016): 348.
8. Asiedu-Gyekye, Isaac Julius, Samuel Frimpong-Manso, Benoit Banga N’guessan, Mahmood Abdulai Seidu, Paul Osei-Prempeh, and Daniel Kwaku Boamah. "Macro-and Microelemental Composition and Toxicity of Unsweetened Natural Cocoa Powder in Sprague-Dawley Rats." Journal of Toxicology 2016 (2016).
9. Asiedu-Gyekye, Isaac Julius, Kennedy Kwami Edem Kukuia, Abdulai Mahmood Seidu, Charles Antwi-Boasiako, Benoit Banga N’guessan, Samuel Frimpong-Manso, Samuel Adjei, Jonathan Zobi, Abraham Terkpertey Tettey, and Alexander Kwadwo Nyarko. "Unsweetened Natural Cocoa Powder Has the Potential to Attenuate High Dose Artemether-Lumefantrine-Induced Hepatotoxicity in Non-Malarious Guinea Pigs." Evidence-Based Complementary and Alternative Medicine 2016 (2016).
10. Amoateng, Patrick, Samuel Adjei, Dorcas Osei-Safo, Believe Ahedor, Seidu A. Mahmood, Benoit B. N’guessan, Isaac J. Asiedu-Gyekye, and Alexander K. Nyarko. "Long-term continuous administration of a hydro-ethanolic extract of Synedrella nodiflora (L) Gaertn in male Sprague-Dawley rats: biochemical, haematological and histopathological changes." Ghana Medical Journal 50, no. 3 (2016): 163-171.
11. Benoit Banga Nguessan*, Kassim Dosso, Boua Narcisse Gnangoran, Patrick Amoateng, Isaac Julius Asiedu-Gyekye, Angoue Paul Yapo: Antibacterial and antispasmodic activities of a dichloromethane fraction of an ethanol extract of stem bark of Piliostigma reticulatum. Journal of Pharmacy & Bioallied Sciences (2015), 7(2) :128-135. *Corresponding author
12. Patrick Amoateng, Samuel Adjei, Dorcas Osei-Safo, Elvis Ofori Ameyaw, Believe Ahedor, Benoit Banga N’guessan, Alexander Kwadwo Nyarko: A hydro-ethanolic extract of Synedrella nodiflora (L.) Gaertn ameliorates hyperalgesia and allodynia in vincristine-induced neuropathic pain in rats. Journal of Basic and Clinical Physiology and Pharmacology (2015), DOI:10.1515/jbcpp-2014-0084.
13. Benoit N’guessan*, Boua Gnangoran, Joseph Sarkodie, Kassim Dosso, Irene Kretchy, Patrick Amoateng, Isaac Asiedu-Gyekye, David Owusu, Alexander Nyarko, Angoue Yapo: Alternative to Conventional Diabetic Management: The Antihyperglycaemic potential of an Ethyl Acetate Fraction Extract of Holarrhena floribunda. European journal of Medicinal plants (2015), 8(4) :175-189. DOI :10.9734/EJMP/2015/17748. *Corresponding author
14. Benoit N’guessan*, Hervé Sanchez, Joffrey Zoll, Florence Ribera, Stéphane Dufour, Eliane Lampert, Michel Kindo, Bernard Geny, Renée Ventura-Clapier, Bertrand Mettauer. Oxidative capacities of cardiac and skeletal muscles of heart transplant recipients: mitochondrial effects of cyclosporin-A and its vehicle Cremophor-EL. Fundam Clin Pharmacol. (2014), Apr; 28(2):151-60. *Corresponding author.
15. K. Dosso, B.B. N’guessan*, A.P. Bidie, B.N. Gnangoran, S. Méité, D. N’guessan, A.P. Yapo, E.E. Ehilé. Antidiarrhoeal activity of an ethanol extract of the stem bark of Piliostigma reticulatum (Caesapiniaceae) in rats. Afr J Tradit Complement Altern Med. (2012), 9(2): 242-249. Corresponding author.