IRB Faculty
The Medical &
Scientific Research Directorate
Dr. Seth Kwabena Amponsah
BSc, MPhil, PhD
Senior Lecturer/Head of Medical Pharmacology, University of Ghana Medical School
skamponsah@ug.edu.gh | +233-243851461 |
Education
- BSc Biochemistry and Nutrition: University of Ghana, Legon, Accra, Ghana (2006)
- MPhil Pharmacology: University of Ghana, Legon, Accra, Ghana (2010)
- PhD Pharmacology: University of Ghana, Legon, Accra, Ghana (2015) ·
- Post-doctoral Fellowship: BANGA-Africa Project, University of Ghana, Legon, Accra, Ghana (2019)
Research Interest
My research interests focus on;
1. Pharmacokinetic studies in human and animal models: population pharmacokinetic modeling; non-compartment pharmacokinetic estimation; pharmacokinetic evaluation of new drug formulations (micro-particles, nano-particles, etc); drug-drug (herb) interaction and possible pharmacokinetic consequence.
1. Pharmacokinetic studies in human and animal models: population pharmacokinetic modeling; non-compartment pharmacokinetic estimation; pharmacokinetic evaluation of new drug formulations (micro-particles, nano-particles, etc); drug-drug (herb) interaction and possible pharmacokinetic consequence.
2. Clinical Pharmacology (infectious disease and antimicrobial stewardship): prudent use of antimicrobials, antimicrobial level monitoring, and efficacy of antimicrobials in patients.
Current projects
1. Efficacy, safety and clinical pharmacology of antimalarials in sickle cell patients
2. Effect of a dietary supplement/extracts on cytochrome P450 enzyme activity and pharmacokinetics of conventional drugs
3. Pharmacokinetic evaluation of pectin-based modified release formulation of carbamazepine
Current projects
1. Efficacy, safety and clinical pharmacology of antimalarials in sickle cell patients
2. Effect of a dietary supplement/extracts on cytochrome P450 enzyme activity and pharmacokinetics of conventional drugs
3. Pharmacokinetic evaluation of pectin-based modified release formulation of carbamazepine
Selected Publications
1. Ogunleye OO, Basu D, Mueller D,……Amponsah SK, et al. Response to the novel corona virus (COVID-19) pandemic across Africa: successes, challenges and implications for the future. Frontiers in Pharmacology, July 2020. doi: 10.3389/fphar.2020.01205.
2. Amponsah SK, N'guessan BB, Akandawen M, Aning A, Agboli SY, Danso EA, Opuni KFM, Asiedu-Gyekye IJ, Appiah-Opong R. Effect of Cellgevity® supplement on selected rat liver Cytochrome P450 enzyme activity and pharmacokinetic parameters of carbamazepine. Evidence-Based Complementary and Alternative Medicine, Volume 2020, Article ID 7956493, 8 pages.
3. Mensah JA, Kukuia KKE, Amoateng P, Osei-Safo D, Adongo DW, Ameyaw EO, Ben IO, Amponsah SK, Asiedu-Gyekye IJ. Monoaminergic and L-arginine-NO-cGMP pathways mediate the antidepressant–like action of alkaloids from the stem bark of Trichilia monadelpha. Scientific African, Volume 8, July 2020, e00422.
4. Allotey-Babington GL, Amponsah SK, Nettey T, Sasu C, Nettey H. Quinine sulphate microparticles as treatment for leishmaniasis. Journal of Tropical Medicine, Volume 2020, Article ID 5278518, 9 pages.
5. Sefah IA, Okatah A, Afriyie DK, Amponsah SK. Adherence to oral hypoglycemic drugs among Type 2 diabetic patients in a resource-poor setting. International Journal of Applied and Basic Medical Research 2020; 10: 102-109.
6. Tetteh-Quarcoo PB, Forson PO, Amponsah SK, Ahenkorah J, Opintan JA, Ocloo JEY, Okine EN, Aryee R, Afutu E, Anang AK, Ayeh-Kumi PF. Persistent urogenital schistosomiasis and its associated morbidity in endemic communities within southern Ghana: suspected praziquantel resistance or reinfection? Medical Sciences 2020; 8(1): E10.
7. Mensah BN, Agyemang IB, Afriyie DK, Amponsah SK. Self-medication practice in Akuse, a rural setting in Ghana. Nigerian Postgraduate Medical Journal 2019; 26: 189-194.
8. Amponsah SK, Opuni KFM, Antwi KA, Kunkpeh VP. Effect of aminophylline on the pharmacokinetics of amikacin in Sprague-Dawley rats. The Journal of Infections in Developing Countries 2019; 13(3): 251-254.
9. Adjei GO, Amponsah SK, Goka BQ, Enweronu-Laryea C, Renner L, Sulley AM, Alifrangis M, Kurtzhals JAL. Population pharmacokinetic estimates suggest elevated clearance and distribution volume of desethylamodiaquine in pediatric patients with sickle cell disease treated with artesunate-amodiaquine. Current Therapeutic Research 2019; 90: 9-15.
10. Amponsah SK, Opuni KFM, Donkor AA. Animal Model Investigation Suggests Betamethasone Alters the Pharmacokinetics of Amikacin. ADMET & DMPK 2018; 6(4): 279-283.
11. Adi-Dako O, Ofori-Kwakye K, Amponsah SK, Boamah I, Kuntworbe N, Oppong EE. Potential of Cocoa Pod Husk Pectin-Based Modified Release Capsules as a Carrier for Chronodelivery of Hydrocortisone in Sprague-Dawley Rats. Journal of Drug Delivery, Volume 2018, Article ID 9825363, 8 pages.
12. Anokye-Kumatia AB, Enimil A, Afriyie DK, Tetteh R, Mensah NK, Amo AA, Gariba BB, Amponsah SK. Highly active antiretroviral therapy adherence among perinatally infected HIV adolescents at a teaching hospital in Ghana. AIDS Care 2018; 30(9): 1144-1146.
13. Afriyie DK, Adu LB, Dzradosi M, Amponsah SK, Ohene-Manu P, Manu-Ofei F. Comparative in vitro activity of ciprofloxacin and levofloxacin against isolated uropathogens in Ghana: a pilot study. The Pan African Medical Journal 2018; 30:194.
14. N’guessan BB, Amponsah SK, Dugbartey GJ, Awuah KD, Dotse E, Aning A, Kukuia KEK, Asiedu-Gyekye IJ, Appiah-Opong R. In Vitro Antioxidant Potential and Effect of a Glutathione-Enhancer Dietary Supplement on Selected Rat Liver Cytochrome P450 Enzyme Activity. Evidence-Based Complementary and Alternative Medicine, Volume 2018, Article ID 7462839, 8 pages.
15. Kukuia KEK, Mensah JA, Amoateng P, Amponsah SK, N’Guessan BB, Asiedu-Gyekye IJ. Antidepressant Potentials of Components from Trichilia monadelpha (Thonn.) J.J. de Wilde in Murine Models. Evidence-Based Complementary and Alternative Medicine, Volume 2018, Article ID 6863973, 11 pages.
2. Amponsah SK, N'guessan BB, Akandawen M, Aning A, Agboli SY, Danso EA, Opuni KFM, Asiedu-Gyekye IJ, Appiah-Opong R. Effect of Cellgevity® supplement on selected rat liver Cytochrome P450 enzyme activity and pharmacokinetic parameters of carbamazepine. Evidence-Based Complementary and Alternative Medicine, Volume 2020, Article ID 7956493, 8 pages.
3. Mensah JA, Kukuia KKE, Amoateng P, Osei-Safo D, Adongo DW, Ameyaw EO, Ben IO, Amponsah SK, Asiedu-Gyekye IJ. Monoaminergic and L-arginine-NO-cGMP pathways mediate the antidepressant–like action of alkaloids from the stem bark of Trichilia monadelpha. Scientific African, Volume 8, July 2020, e00422.
4. Allotey-Babington GL, Amponsah SK, Nettey T, Sasu C, Nettey H. Quinine sulphate microparticles as treatment for leishmaniasis. Journal of Tropical Medicine, Volume 2020, Article ID 5278518, 9 pages.
5. Sefah IA, Okatah A, Afriyie DK, Amponsah SK. Adherence to oral hypoglycemic drugs among Type 2 diabetic patients in a resource-poor setting. International Journal of Applied and Basic Medical Research 2020; 10: 102-109.
6. Tetteh-Quarcoo PB, Forson PO, Amponsah SK, Ahenkorah J, Opintan JA, Ocloo JEY, Okine EN, Aryee R, Afutu E, Anang AK, Ayeh-Kumi PF. Persistent urogenital schistosomiasis and its associated morbidity in endemic communities within southern Ghana: suspected praziquantel resistance or reinfection? Medical Sciences 2020; 8(1): E10.
7. Mensah BN, Agyemang IB, Afriyie DK, Amponsah SK. Self-medication practice in Akuse, a rural setting in Ghana. Nigerian Postgraduate Medical Journal 2019; 26: 189-194.
8. Amponsah SK, Opuni KFM, Antwi KA, Kunkpeh VP. Effect of aminophylline on the pharmacokinetics of amikacin in Sprague-Dawley rats. The Journal of Infections in Developing Countries 2019; 13(3): 251-254.
9. Adjei GO, Amponsah SK, Goka BQ, Enweronu-Laryea C, Renner L, Sulley AM, Alifrangis M, Kurtzhals JAL. Population pharmacokinetic estimates suggest elevated clearance and distribution volume of desethylamodiaquine in pediatric patients with sickle cell disease treated with artesunate-amodiaquine. Current Therapeutic Research 2019; 90: 9-15.
10. Amponsah SK, Opuni KFM, Donkor AA. Animal Model Investigation Suggests Betamethasone Alters the Pharmacokinetics of Amikacin. ADMET & DMPK 2018; 6(4): 279-283.
11. Adi-Dako O, Ofori-Kwakye K, Amponsah SK, Boamah I, Kuntworbe N, Oppong EE. Potential of Cocoa Pod Husk Pectin-Based Modified Release Capsules as a Carrier for Chronodelivery of Hydrocortisone in Sprague-Dawley Rats. Journal of Drug Delivery, Volume 2018, Article ID 9825363, 8 pages.
12. Anokye-Kumatia AB, Enimil A, Afriyie DK, Tetteh R, Mensah NK, Amo AA, Gariba BB, Amponsah SK. Highly active antiretroviral therapy adherence among perinatally infected HIV adolescents at a teaching hospital in Ghana. AIDS Care 2018; 30(9): 1144-1146.
13. Afriyie DK, Adu LB, Dzradosi M, Amponsah SK, Ohene-Manu P, Manu-Ofei F. Comparative in vitro activity of ciprofloxacin and levofloxacin against isolated uropathogens in Ghana: a pilot study. The Pan African Medical Journal 2018; 30:194.
14. N’guessan BB, Amponsah SK, Dugbartey GJ, Awuah KD, Dotse E, Aning A, Kukuia KEK, Asiedu-Gyekye IJ, Appiah-Opong R. In Vitro Antioxidant Potential and Effect of a Glutathione-Enhancer Dietary Supplement on Selected Rat Liver Cytochrome P450 Enzyme Activity. Evidence-Based Complementary and Alternative Medicine, Volume 2018, Article ID 7462839, 8 pages.
15. Kukuia KEK, Mensah JA, Amoateng P, Amponsah SK, N’Guessan BB, Asiedu-Gyekye IJ. Antidepressant Potentials of Components from Trichilia monadelpha (Thonn.) J.J. de Wilde in Murine Models. Evidence-Based Complementary and Alternative Medicine, Volume 2018, Article ID 6863973, 11 pages.