IRB Faculty
The Medical &
Scientific Research Directorate
Prof. Kwamena W. C Sagoe
MSc., PhD.
Associate Professor/Head of Virology Unit, Department of Medical Microbiology
kwsagoe@ug.edu.gh | +233277408528 |
Education
PhD in Microbiology (Virology), University of Ghana (2010)
MSc in Clinical Virology (Research Based), Karolinska Institutet, Stockholm, Sweden (1999)
Course on laboratory diagnosis on HIV infections. National Inst. for Infectious Diseases, Tokyo, Japan (13th Jan-21st Feb,’03)
W.H.O. Training Course in Vaccine Potency Testing and Polio Diagnostic Procedures; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon (14-30th March, 1994)
MSc in Clinical Virology (Research Based), Karolinska Institutet, Stockholm, Sweden (1999)
Course on laboratory diagnosis on HIV infections. National Inst. for Infectious Diseases, Tokyo, Japan (13th Jan-21st Feb,’03)
W.H.O. Training Course in Vaccine Potency Testing and Polio Diagnostic Procedures; Noguchi Memorial Institute for Medical Research, University of Ghana, Legon (14-30th March, 1994)
Research Interest
Main research interests and focus are in Public Health and Molecular Virology. These specific interests include the effects of sequence variability of viruses and the implications for epidemiology, sero-diagnosis, pathogenesis, immune responses, treatment and vaccine design and development. My work therefore includes a substantial amount of molecular bioinformatics. Main area of work has been in blood borne viruses including human retroviruses and hepatitis viruses. Also been involved in human rotaviruses surveillance.
Current projects
1. NGS analysis of HIV-1 drug resistance in treatment naive patients
2. Prevalence and emergence of dolutegravir resistance in adolescents and adults
3. Hepatitis B virus infections in different populations and communities
4. SARS-CoV-2: epidemiology in febrile individuals and the use of hydrogen peroxide to limit transmission
Selected Publications
1. Obeng BM, Bonney EY, Asamoah-Akuoko L, Nii-Trebi NI, Mawuli G, Abana C Z-Y, Sagoe KWC. Transmitted drug resistance mutations and subtype diversity amongst HIV-1 sero-positive voluntary blood donors in Accra, Ghana. Virol J. 2020;17(1):114. Published 2020 Jul 24. doi:10.1186/s12985-020-01386-y
2. Ayettey AS, Quakyi IA, Ayettey-Anie HNG, Sagoe KW et al. A Case for Hydrogen Peroxide Mouthwash and Gargle to Limit SARS-CoV-2 Infection. BMJ 2020;368:m1252
3. Boyce CL, Willis S, Archampong TNA, Lartey M, Sagoe KW, Obo-Akwa A, Kenu E,Kwara A, Blackard JT. Identification of hepatitis B virus genotype A/Erecombinants in Ghana. Virus Genes. 2019 Oct;55(5):707-712. doi:10.1007/s11262-019-01690-y. Epub 2019 Jul 25. PubMed PMID: 31346975; PubMedCentral PMCID: PMC6750976.
4. Archampong T, Ojewale O, Bears K, Chen Y, Lartey M, Sagoe KW, Obo-Akwa A, GongY, Langaee T, Kwara A. Relationship between ABCC4 SNPs and hepatitis B virussuppression during tenofovir-containing antiretroviral therapy in patients withHIV/HBV coinfection. J Acquir Immune DeficSyndr. 2019 Jul 3. doi:10.1097/QAI.0000000000002136. [Epub ahead of print] PubMed PMID: 31335591.
2019; 82 (4):421-425.
5. Abana CZ, Sagoe KWC, Bonney EY, Maina EK, Aziati ID, Agbosu E, Mawuli G, StyerLM, Ishikawa K, Brandful JAM, Ampofo WK. Drug resistance mutations and viral loadin humanimmunodeficiency virus type 2 and dual HIV-1/HIV-2 infected patients in Ghana. Medicine (Baltimore). 2019 Feb;98(6):e14313. doi:10.1097/MD.0000000000014313. PubMed PMID: 30732150; PubMed Central PMCID:PMC6380870.
6. Damanka SA, Agbemabiese CA, Lartey BL, Dennis FE, Asamoah FK, Adiku TK, Enweronu-Laryea CC, Sagoe KW, Ofori MF, Armah GE. Identification of Amino Acid Substitutions Within the VP7 Genes of G2 Rotavirus Strains in Ghana. Pediatr Infect Dis J. 2018 Nov;37(11):1172-1174. doi: 10.1097/INF.0000000000002037. PubMed PMID: 30312266.
7. Martin-Odoom A, Brown CA, Odoom JK, Bonney EY, Ntim NAA, Delgado E, Lartey M, Sagoe KW, Adiku T, Ampofo WK. Emergence of HIV-1 drug resistance mutations inmothers on treatment with a history of prophylaxis in Ghana. Virol J. 2018 Sep17;15(1):143. doi: 10.1186/s12985-018-1051-2. PubMed PMID: 30223845; PubMedCentral PMCID: PMC6142311.
8. Enweronu-Laryea CC, Armah G, Sagoe KW, Ansong D, Addo-Yobo E, Diamenu SK, Mwenda JM, Parashar UD, Tate JE. Sustained impact of rotavirus vaccine introduction on rotavirus gastroenteritis hospitalizations in children <5 years of age, Ghana, 2009-2016. Vaccine. 2018 May 8. pii: S0264-410X(18)30245-7. doi: 10.1016/j.vaccine.2018.02.058. [Epub ahead of print] PubMed PMID: 29752020.
9. N'Guessan KF, Boyce C, Kwara A, Archampong TNA, Lartey M, Sagoe KW, Kenu E, Obo-Akwa A, Blackard JT. Human pegivirus (HPgV) infection in Ghanaians co-infected with human immunodeficiency virus (HIV) and hepatitis B virus (HBV). Virus Genes. 2018 Jun;54(3):361-367. doi: 10.1007/s11262-018-1555-2. Epub 2018 Mar 17. PubMed PMID: 29551002; PubMed Central PMCID: PMC5953819.
10. Lartey BL, Damanka S, Dennis FE, Enweronu-Laryea CC, Addo-Yobo E, Ansong D,Kwarteng-Owusu S, Sagoe KW, Mwenda JM, Diamenu SK, Narh C, Binka F, Parashar U,Lopman B, Armah GE. Rotavirus strain distribution in Ghana pre- and post-rotavirus vaccine introduction. Vaccine. 2018 Jan 20. pii: S0264-410X(18)30034-3.doi: 10.1016/j.vaccine.2018.01.010. [Epub ahead of print] PubMed PMID: 29371014.
11. Apiung T, Ndanu TA, Mingle JA, Sagoe KW. Hepatitis B virus surface antigen and antibody markers in children at a major paediatric hospital after the pentavalent DTP-HBV-Hib vaccination. Ghana Med J. 2017 Mar;51(1):13-19. PubMed PMID: 28959067; PubMed Central PMCID: PMC5611951.
12. Boyce CL, Ganova-Raeva L, Archampong TNA, Lartey M, Sagoe KW, Obo-Akwa A, KenuE, Kwara A, Blackard JT. Identification and comparative analysis of hepatitis Bvirus genotype D/E recombinants in Africa. Virus Genes. 2017 Aug;53(4): 538-547.doi: 10.1007/s11262-017-1469-4. Epub 2017 May 31. PubMed PMID: 28567562; PubMedCentral PMCID: PMC5710801.
13. Sagoe, K. W., Duedu, K. O., Ziga, F., Agyei, A. A., Adiku, T. K., Lartey, M., Mingle, J. A. &Arens, M. (2016). Short-term treatment outcomes in human immunodeficiency virus type-1 and hepatitis B virus co-infections. Ann Clin Microbiol Antimicrob, 15(1), 38. doi:10.1186/s12941-016-0152-2
14. Archampong, T. N., Boyce, C. L., Lartey, M., Sagoe, K. W., Obo-Akwa, A., Kenu, E., Blackard, J. T. & Kwara, A. (2016). HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients. Antivir Ther. May 11. doi:10.3851/IMP3055
15. Sagoe, K. W., Duedu, K. O., Seshie, M., Agyei, A. A. &Zigah F. (2016). Decay of soluble CD30 and HIV-1 plasma viral load during early highly active antiretroviral therapy: A short-term longitudinal study. J Microbial BiochemTechnol, 8(2), 090-096.